Insulin
We can say when insulin spikes (due to increase of glucose in blood), the body react by favoring storage of dietary fats that have recently been eaten and moves away from fat burning.
From Insulin Resistance
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Studies have found that insulin resistance itself is associated with huge increases in one's risk of cancer (up to twelvefold), Alzheimer's disease (fivefold), and death from cardiovascular disease (almost sixfold) - Outlive
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