Example Adenosine Block per Day
To illustrate how 2 cups will have much different effect on adenosine blocking throughout the day than 1 cup let's plot caffeine level in body versus ballpark adenosine blocking correlated with levels of caffeine in body.
Setup
- On the left vertical axis of the graph we will have caffeine level in body. (in pencil).
- On the right vertical axis of the graph we will have receptor occupancy percentage. (in blue).
- Horizontal axis will be time in hours.
Adenosine Receptor blocking (occupancy) in relationship to caffeine is taken from this study.
Example #1 Outlier metabolism (caffeine half life 2 hours)
This will be an outlier in metabolism having half life of 2-hours.
- In this example 1st cup of coffee will be taken at 0 hour mark.
- 2nd cup of coffee will be taken at 8 hours mark.
Shows that there is quite a difference in receptor occupancy (graphed in blue with 2 cups than what it would have been with 1 cup)
Example #2 in range of median half life metabolism of caffeine (caffeine half life 4hours)
In this example we still take first cup at 0 mark and 2nd cup at 8 hour mark. But half life is at 4 hours.
Looking at daily area under the curve of adenosine blocking 1 cup does look similar to 2 cups. However, if we were to extend the graph we end up seeing that with 2 cups in this hypothetical example we are blocking Adenosine during our sleep, starting our sleep with about 30% adenosine receptor blockade.
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