LDL = Low-Density Lipoprotein
LDL is less dense because it carries more lipids (cholesterol and triglycerides) relative to protein.
Wrapped by one apoB with variance of amount of Cholesterol
LDL is wrapped by 1-apoB particle.
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the amount of cholesterol per LDL particle varies >2-fold between individuals - pmc.nih.gov
Ideally LDL-C is in 10 to 20 mg/dL range (Much lower than current guidelines)
“Many doctors, and in fact many of you reading this, might be shocked to see such a low LDL-C target: 10 to 20 mg/dL? Most guidelines consider lowering LDL-C to 70 mg/dL to be “aggressive,” even for secondary prevention in high-risk patients, such as those who have already had a heart attack. It’s also natural to ask whether such extremely low levels of LDL-C and apoB are safe, given the ubiquity and importance of cholesterol in the human body. But consider the following: infants, who presumably require the most cholesterol, in order to meet the enormous demands of their rapidly growing central nervous system, have similarly low levels of circulating cholesterol, without any developmental impairment. Why? Because the total amount of cholesterol contained in all our lipoproteins—not just LDL, but also HDL and VLDL—represents only about 10 to 15 percent of our body’s total pool of cholesterol. So the concern is unwarranted, as demonstrated by scores of studies showing no ill effects from extremely low LDL concentrations.” - Outlive
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